Date:

MSU scientists crack medieval bone code

1000 year old Vertebra was ravaged by brucellosis. Photo by G.L. Kohuth

Two teams of Michigan State University researchers – one working at a medieval burial site in Albania, the other at a DNA lab in East Lansing – have shown how modern science can unlock the mysteries of the past.

The scientists are the first to confirm the existence of brucellosis, an infectious disease still prevalent today, in ancient skeletal remains.

- Advertisement -

The findings, which appear in the American Journal of Physical Anthropology, suggest brucellosis has been endemic to Albania since at least the Middle Ages.

Although rare in the United States, brucellosis remains a major problem in the Mediterranean region and other parts of the world. Characterized by chronic respiratory illness and fever, brucellosis is acquired by eating infected meat or unpasteurized dairy products or by coming into contact with animals carrying the brucella bacteria.

Todd Fenton, associate professor of anthropology, said advanced DNA testing at MSU allowed the researchers to confirm the existence of the disease in skeletons that were about 1,000 years old.

“For years, we had to hypothesize the cause of pathological conditions like this,” Fenton said. “The era of DNA testing and the contributions that DNA can make to my work are really exciting.”

Here’s how the discovery came about.

Spinal damage caused by Brucellosis : Courtesy photo

Fenton and a group of MSU graduate students were serving as the bioarcheologists, or bone specialists, for a multinational team of archaeologists excavating sites in the ancient Albanian city of Butrint. Once a large Roman colony, Butrint in its final centuries served as an outpost of the Byzantine Empire until it was abandoned in the Middle Ages due to flooding.

- Advertisement -

Fenton and his team developed biological profiles of the human remains, which included determining sex, age and skeletal pathologies, or health histories. Vertebrae from two of the Byzantine-era skeletons – both adolescent males from the 10th century to the 13th century – had significant lesions, leading the researchers to theorize the boys had suffered from tuberculosis.

Samples of the ancient bone were sent to the forensic DNA lab in East Lansing, which is headed by David Foran, director of MSU’s Forensic Science Program. Foran and his team of graduate students took tiny portions of the bone, extracted DNA and tested it for any residual DNA that might still exist from the expected pathogen.

But the results came back negative for tuberculosis.

Fenton’s team re-examined the bones that tested negative for tuberculosis and concluded the disease might instead be brucellosis. The infection from brucellosis and tuberculosis causes similar damage – basically eating away the bone – although no one had ever confirmed brucellosis in human bone recovered from an archaeological site.

Foran’s team then developed a different set of tests for detecting the brucella bacteria and undertook a new round of testing on the diseased vertebrae.

This time the results came back positive for brucellosis.

Foran said the collaboration on the project highlights the benefits of modern science and interdisciplinary research, even when the respective research teams are some 5,000 miles apart.

“In this case it was a combination of inquisitiveness, persistence and of course collaboration,” Foran said. “It is amazing to find something brand new in something that is a thousand years old.”

Co-investigators on the project included Michael Mutolo, former master’s student in forensic science; Lindsey Jenny, who recently completed her doctorate degree in anthropology; and Amanda Buszek, current master’s student in forensic science.

Background:

Michigan State University has been working to advance the common good in uncommon ways for more than 150 years. One of the top research universities in the world, MSU focuses its vast resources on creating solutions to some of the world’s most pressing challenges, while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.

HeritageDaily Archaeology News Press Release – News for Archeology by Archaeologists

- Advertisement -

Stay Updated: Follow us on iOS, Android, Google News, Facebook, Instagram, Twitter, Threads, TikTok, LinkedIn, and our newsletter

spot_img
Mark Milligan
Mark Milligan
Mark Milligan is a multi-award-winning journalist and the Managing Editor at HeritageDaily. His background is in archaeology and computer science, having written over 8,000 articles across several online publications. Mark is a member of the Association of British Science Writers (ABSW), the World Federation of Science Journalists, and in 2023 was the recipient of the British Citizen Award for Education, the BCA Medal of Honour, and the UK Prime Minister's Points of Light Award.
spot_img
spot_img

Mobile Application

spot_img

Related Articles

Soldier’s wrist purse discovered at Roman legionary camp

Archaeologists have discovered a fragment of a soldier's wrist purse at the site of a temporary Roman camp in South Moravia, Czech Republic.

Lost equestrian sculpture found buried in Toul

Archaeologists from the National Institute for Preventive Archaeological Research (Inrap) have discovered an equestrian sculpture during excavations in Toul, France.

Roman-Era settlement unearthed in Alès

A recent excavation led by Inrap has uncovered a remarkably well-preserved Roman-era settlement on the slopes of the Hermitage hill overlooking Alès, southern France.

Excavations in Olympos reveal ancient mosaics and sacred inscriptions

Excavations in Olympos, Antalya province, have uncovered mosaic floors and inscriptions within a 5th-century church, part of a year-round project backed by Türkiye’s Ministry of Culture and Tourism.

Mammoth bones uncovered during road construction works

The Construction of the S17 Piaski–Hrebenne highway near the Arabunie village in Zamość County has revealed the remains of what is believed to be either a woolly mammoth or a forest elephant.

Hidden Medieval tower unearthed in Lublin reveals forgotten chapter of city’s past

Archaeologists have uncovered the remains of a previously undocumented medieval tower within the grounds of the former Pobernardine monastery complex, near the Church of the Conversion of Saint Paul on Bernardyńska Street.

Sinkhole reveals lost remains of medieval hospital

A sinkhole that formed outside the York Theatre Royal has led to the discovery of what could be one of England’s largest medieval hospitals.

Chalcolithic cultural treasures unearthed in Caucasus

Archaeologists from the Institute of Archaeology of the Russian Academy of Sciences have uncovered 13 Chalcolithic-era sites, each yielding a wealth of cultural artefacts and material evidence.